A new pandemic caused by 'Red Rain' has struck the Far East Branch. The game takes place 3 years after God Eater. There's a limit of 100 points that can be used to equip them, with each Link Device consuming anywhere from 10 to 60 points.

Unlocked through Character Episodes, Link Support Devices allow players to gain status effects in battle, such as 10% additional attack power from two to five minutes into the mission. Completing these give players materials, items, or even additional Blood Arts. Players can interact with various characters, who may invite them to optional side missions. Finishing a mission with a higher rank gives more experience points to the currently equipped Blood Art and other Blood Arts of the same variant. Raising a Blood Art's proficiency requires completing missions. The Blood Arts, one of the new additions in the game, are 'attack add-on' that augment normal attacks of all manner into stronger attacks, thus either unlocking new Blood Arts or converting existing ones into much stronger variants. Most of the existing weapons have additional features and skills, such as the Short Blade's 'Rising Edge' upward slash that sends the character into mid-air and can continue to an aerial combo, and the Long Blade's 'Zero Stance' skill that can cancel attack animations, thus allowing longer combos or cancel an attack to block or dodge attacks. The Shotgun is a large cannon that sprays bullets, allowing increased damage the closer the player is to the opponent. The Variant Scythe is a large scythe that can extend for a long range. The Charge Spear is a large spear that can be 'charged' to form a sharpened organic blade.

The Boost Hammer is a hammer fitted with a rocket booster. In comparison to Gods Eater Burst, there are new features and additions such as the four new weapons, the Boost Hammer, Charge Spear, the Variant Scythe and the Shotgun. The sample screenshot of the game for the PS Vita version

God eater rage burst